| 水溶液中芘的荧光被核酸碱基猝灭的研究 |
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| 引用本文： | 张新宇,金声,明阳福,叶建萍,樊美公.水溶液中芘的荧光被核酸碱基猝灭的研究[J].影像科学与光化学,1994,12(4):352-357. |
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| 作者姓名： | 张新宇 金声 明阳福 叶建萍 樊美公 |
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| 作者单位： | 1. 中国科学院感光化学研究所, 北京100101;2. 北京大学化学系, 北京100871;3. 兰州大学, 应用有机化学国家重点实验室, 兰州730000 |
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| 摘 要： | 众所周知,稠环芳烃是一类具有致癌性的物质.虽然对其致癌机理的认识尚未形成一致的看法,但一般都认为同稠环芳烃与DNA,蛋白质等生物活性物质的相互作用有关.因为致癌物后的致癌作用最终都是通过损伤细胞中的DNA而实现的.
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| 关 键 词： | 芘 荧光猝灭 核酸碱基 |
| 收稿时间： | 1993-11-19 |
STUDIES ON THE QUENCHING OF PYRENEFLUORESCENCE BY NUCLEIC ACIDBASES IN AQUEOUS SOLUTION |
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| ZHANG XIN-YU,JIN SHENG,MING,YANG-FU,YE JIAN-PING,FAN MEI-GONG.STUDIES ON THE QUENCHING OF PYRENEFLUORESCENCE BY NUCLEIC ACIDBASES IN AQUEOUS SOLUTION[J].Imaging Science and Photochemistry,1994,12(4):352-357. |
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| Authors: | ZHANG XIN-YU JIN SHENG MING YANG-FU YE JIAN-PING FAN MEI-GONG |
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| Affiliation: | Institute of Photographic Chemistry, Academia Sinica, Beijing 100101, P. R. China |
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| Abstract: | The quenching of pyrene fluorescence by nucleic acid bases solution wasstudied.Fluorescence of pyrene is strongly quenched by pyrimidines, but slightly bypurines.The analysis of fluorescence quenching processes shows that quenching by purinesis static mechanism and quenching by pyrimidines is dynamic one.These resalts indicatethat the π-π electron interaction between pyrene and nucleic acid bases exists and thisinteraction may probably lead to the formation of non-emission exciplex between excitedpyrene and pyrimidine and ground state complex between pyrene and purines. |
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| Keywords: | pyrene fluorescence nucleic acid bases quenching |
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