An Allosteric Receptor by Simultaneous “Casting” and “Molding” in a Dynamic Combinatorial Library |
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| Authors: | Dr. Jianwei Li Piotr Nowak Prof. Dr. Sijbren Otto |
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| Affiliation: | Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen (The Netherlands) http://www.otto‐lab.com |
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| Abstract: | Allosteric synthetic receptors are difficult to access by design. Herein we report a dynamic combinatorial strategy towards such systems based on the simultaneous use of two different templates. Through a process of simultaneous casting (the assembly of a library member around a template) and molding (the assembly of a library member inside the binding pocket of a template), a Russian‐doll‐like termolecular complex was obtained with remarkable selectivity. Analysis of the stepwise formation of the complex indicates that binding of the two partners by the central macrocycle exhibits significant positive cooperativity. Such allosteric systems represent hubs that may have considerable potential in systems chemistry. |
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| Keywords: | allosteric receptors dynamic combinatorial chemistry molecular dynamics supramolecular chemistry systems chemistry |
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