Facile Synthesis of Gd(OH)3‐Doped Fe3O4 Nanoparticles for Dual‐Mode T1‐ and T2‐Weighted Magnetic Resonance Imaging Applications |
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| Authors: | Hongdong Cai Xiao An Shihui Wen Jingchao Li Guixiang Zhang Xiangyang Shi Mingwu Shen |
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| Affiliation: | 1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, P. R. China;2. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, P. R. China;3. Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P. R. China |
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| Abstract: | The facile hydrothermal synthesis of polyethyleneimine (PEI)‐coated iron oxide (Fe3O4) nanoparticles (NPs) doped with Gd(OH)3 (Fe3O4‐Gd(OH)3‐PEI NPs) for dual mode T1‐ and T2‐weighted magnetic resonance (MR) imaging applications is reported. In this approach, Fe3O4‐Gd(OH)3‐PEI NPs are synthesized via a hydrothermal method in the presence of branched PEI and Gd(III) ions. The PEI coating onto the particle surfaces enables further modification of poly(ethylene glycol) (PEG) in order to render the particles with good water dispersibility and improved biocompatibility. The formed Fe3O4‐Gd(OH)3‐PEI‐PEG NPs have a Gd/Fe molar ratio of 0.25:1 and a mean particle size of 14.4 nm and display a relatively high r2 (151.37 × 10?3m ?1 s?1) and r1 (5.63 × 10?3m ?1 s?1) relaxivity, affording their uses as a unique contrast agent for T1‐ and T2‐weighted MR imaging of rat livers after mesenteric vein injection of the particles and the mouse liver after intravenous injection of the particles, respectively. The developed Fe3O4‐Gd(OH)3‐PEI‐PEG NPs may hold great promise to be used as a contrast agent for dual mode T1‐ and T2‐weighted self‐confirmation MR imaging of different biological systems. |
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| Keywords: | Gd(OH)3 nanoparticles iron oxide nanoparticles T1‐weighted MR imaging T2‐weighted MR imaging |
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