Enzyme‐MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy |
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| Authors: | Xizhen Lian Dr Yanyan Huang Yuanyuan Zhu Dr Yu Fang Prof Rui Zhao Elizabeth Joseph Jialuo Li Prof Jean‐Philippe Pellois Prof Hong‐Cai Zhou |
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| Affiliation: | 1. Department of Chemistry, Texas A&M University, College Station, TX, USA;2. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China;3. Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA |
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| Abstract: | Prodrug activation, by exogenously administered enzymes, for cancer therapy is an approach to achieve better selectivity and less systemic toxicity than conventional chemotherapy. However, the short half‐lives of the activating enzymes in the bloodstream has limited its success. Demonstrated here is that a tyrosinase‐MOF nanoreactor activates the prodrug paracetamol in cancer cells in a long‐lasting manner. By generating reactive oxygen species (ROS) and depleting glutathione (GSH), the product of the enzymatic conversion of paracetamol is toxic to drug‐resistant cancer cells. Tyrosinase‐MOF nanoreactors cause significant cell death in the presence of paracetamol for up to three days after being internalized by cells, while free enzymes totally lose activity in a few hours. Thus, enzyme‐MOF nanocomposites are envisioned to be novel persistent platforms for various biomedical applications. |
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| Keywords: | cancer drug delivery enzymes metal– organic frameworks nanoparticles |
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