Direct Access to Aryl Bis(trifluoromethyl)carbinols from Aryl Bromides or Fluorosulfates: Palladium‐Catalyzed Carbonylation |
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| Authors: | Katrine Domino Cedrick Veryser Benjamin A Wahlqvist Cecilie Gaardbo Dr Karoline T Neumann ProfDr Kim Daasbjerg Prof?Dr Wim M De?Borggraeve Prof?Dr Troels Skrydstrup |
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| Affiliation: | 1. Carbon Dioxide Activation Center (CADIAC), Department of Chemistry and the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, Denmark;2. Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Leuven, Belgium |
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| Abstract: | A palladium‐catalyzed carbonylative approach for the direct conversion of (hetero)aryl bromides into their α,α‐bis(trifluoromethyl)carbinols is described, and it employs only stoichiometric amounts of carbon monoxide and trifluoromethyltrimethylsilane. In addition, aryl fluorosulfates proved highly compatible with these reaction conditions. The method is tolerant of a diverse set of functional groups, and it is adaptable to late‐stage carbon‐isotope labeling. |
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| Keywords: | aryl halides carbonylation fluorine isotopic labeling palladium |
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