Next‐Generation o‐Nitrobenzyl Photolabile Groups for Light‐Directed Chemistry and Microarray Synthesis |
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| Authors: | Nicole Kretschy Ann‐Katrin Holik Prof. Veronika Somoza Dr. Klaus‐Peter Stengele Prof. Mark M. Somoza |
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| Affiliation: | 1. Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Althanstrasse 14 (UZA II), 1090 Vienna (Austria);2. Department of Nutritional and Physiological Chemistry, Faculty of Chemistry, University of Vienna (Austria);3. Christian Doppler Laboratory for Bioactive Aroma Compounds, University of Vienna (Austria);4. Roche Diagnostics, Penzberg (Germany) |
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| Abstract: | ![]()
Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o‐nitrobenzyl derivatives, benzoyl‐ and thiophenyl‐NPPOC, undergo photo‐deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two‐ and twelvefold increase in photo‐deprotection efficiency was proven using photolithograph synthesis of microarrays. |
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| Keywords: | microarrays photochemistry photolysis protecting groups |
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