Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas |
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| Authors: | Guang Yang Miriam O'Duill Prof Véronique Gouverneur Dr Marie Pierre Krafft |
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| Affiliation: | 1. Institut Charles Sadron (CNRS), University of Strasbourg, 23 rue du Loess, 67034 Strasbourg (France);2. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA (UK) |
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| Abstract: | Perfluorohexane gas when introduced in the air atmosphere above a film of phospholipid self‐supported on an aqueous solution of C2F5‐labeled compounds causes the recruitment and immobilization of the latter in the interfacial film. When the phospholipid forms a liquid‐condensed Gibbs monolayer, which is the case for dipalmitoylphosphatidylcholine (DPPC), the C2F5‐labeled molecule remains trapped in the monolayer after removal of F‐hexane. Investigations involve bubble profile analysis tensiometry (Gibbs films), Langmuir monolayers and microbubble experiments. The new phenomenon was utilized to incorporate a hypoxia biomarker, a C2F5‐labeled nitrosoimidazole (EF5), in microbubble shells. This finding opens perspectives in the delivery of fluorinated therapeutic molecules and biomarkers. |
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| Keywords: | drug delivery fluorocarbons microbubbles molecular recognition phospholipid interfaces |
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