| 生物高分子的单分子物理研究 |
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| 引用本文： | 秦猛,曹毅.生物高分子的单分子物理研究[J].物理学进展,2011,31(3):168-184. |
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| 作者姓名： | 秦猛 曹毅 |
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| 作者单位： | 南京固体微结构物理国家重点实验室南京大学,南京,210093 |
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| 基金项目： | supported by NNSFC(Nos.10904064,10834002 and 11074115); NBRPC(No.2007CB814800); NS-FJP(No.BK2009008); NCET |
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| 摘 要： | 许多生物大分子通过机械力来调控其结构与生物功能。它们能够产生，感应，传递和响应力学信号，并且做出相应的构象变化。单分子力谱被广泛地用于表征这些生物分子在其生理环境下的构象变化，从而研究机械力对结构和功能的调控作用。我们将在这一综述中，总结不同生物大分子力谱与其结构之间的对应关系，和各种相互作用对生物大分子力学性能的贡献和调控。这些研究也使得基于原子力显微镜的单分子力谱成为一个多功能的研究工具，把传统的生物化学和生物物理拓展到单分子层面。
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| 关 键 词： | 单分子力谱 原子力显微镜 蛋白质 多糖 核酸 生物材料 |
Single Molecule Force Spectroscopy on Biomacromolecules |
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| Qin Meng,Cao Yi National Laboratory of Solid State Microstructure.Single Molecule Force Spectroscopy on Biomacromolecules[J].Progress In Physics,2011,31(3):168-184. |
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| Authors: | Qin Meng Cao Yi National Laboratory of Solid State Microstructure |
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| Affiliation: | Qin Meng,Cao Yi National Laboratory of Solid State Microstructure and Department of Physics,Nanjing University,Nanjing 210093,P. R. China |
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| Abstract: | Many biomacromolecules use mechanical force as a critical regulator for their structure and biologicalfunctions. They generate, sense, transduce and response to mechanical force through their conforma-tional changes. Single molecule atomic force microscopy techniques have been widely used to study theconformation of individual biomacromolecules under force in their biological environment and provideessential information of the interplay of structure, function and force. In this review, we show that howthe n... |
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| Keywords: | single molecule force spectroscopy atomic force microscope protein polysaccharide nucleic acid biomaterials |
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