Ligand‐Controlled Regiodivergent Palladium‐Catalyzed Decarboxylative Allylation Reaction to Access α,α‐Difluoroketones |
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| Authors: | Ming‐Hsiu Yang Douglas L Orsi Prof?Dr Ryan A Altman |
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| Affiliation: | Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045 (USA) |
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| Abstract: | α,α‐Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. To access the α‐allyl‐α,α‐difluoroketone substructure, complementary palladium‐catalyzed decarboxylative allylation reactions were developed to provide linear and branched α‐allyl‐α,α‐difluoroketones. For these orthogonal processes, the fluorination pattern of the substrate enabled the ligands to dictate the regioselectivity of the transformations. |
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| Keywords: | allylation fluorine palladium phosphine ligands regioselectivity |
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