Enantiomeric separation of indoxacarb on an amylose‐based chiral stationary phase and its application in study of indoxacarb degradation in water |
| |
| Authors: | Yuping Zhang Kankan Zhang Baoan Song Hurong Ling Zhining Li Meichuan Li Deyu Hu |
| |
| Affiliation: | 1. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China;2. Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang, China |
| |
| Abstract: | Direct semipreparative enantioseparation of indoxacarb was performed on a semipreparative Chiralpak IA column using normal‐phase high‐performance liquid chromatography (HPLC) with n‐hexane–isopropanol–ethyl acetate (70:20:10) mixture as mobile phase. Degradation of indoxacarb (2.33S + 1R) and its two enantiopure isoforms in three aqueous buffer solutions and four water samples collected from natural water sources was then elucidated by HPLC analysis on Chiralpak IA column. Degradation of all three indoxacarbs complied with first‐order kinetics and demonstrated linearity with regression coefficients R2 > 0.88. Indoxacarb (2.33S + 1R) underwent enantioselective degradation in river water, rain water, and buffer solution of pH 7.0. Enantiopure S‐(+)‐indoxacarb and R‐(?)‐indoxacarb were both found to be configurationally stable in water. Copyright © 2014 John Wiley & Sons, Ltd. |
| |
| Keywords: | indoxacarb enantiomers semipreparative enantioseparation Chiralpak IA column enantioselective degradation water |
|
|
