Synthesis and Antimicrobial Activity of Some Novel Hydrazide,Pyrazole, Triazine,Isoxazole, and Pyrimidine Derivatives |
| |
| Authors: | Hala M Refat A A Fadda |
| |
| Affiliation: | 1. Department of Chemistry, Faculty of Education, Suez Canal University, Al‐Arish, Egypt;2. Department of Chemistry, Faculty of Science, Mansoura University, El‐Mansoura, Egypt |
| |
| Abstract: | In continuation of our efforts to find a new class of antimicrobial agents, a series of pyrazole, 1,2,4‐triazine, isoxazole, pyrimidine, and other related products containing a hydrazide moiety were prepared via the reaction of 2‐cyano‐N‐((2‐methoxynaphthalen‐1‐yl)methylene) acetohydrazide ( 1 ) with appropriate chemical reagents. These compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration against most of test organisms was performed. Among the tested compounds 4 , 5 , 6 , and 16 displayed excellent antimicrobial activity. All the synthesized products were confirmed by elemental analysis, IR, 1H‐NMR, 13C‐NMR, and mass spectral data. |
| |
| Keywords: | |
|
|
