Synthesis and Antioxidant Evaluation of Some Nicotinonitriles |
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| Authors: | Moustafa A Gouda Moged A Berghot Ghada E Abd El‐Ghani Abd El‐Galil M Khalil |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science and Arts, Taibah University, Ulla, Saudi Arabia;2. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt |
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| Abstract: | One‐pot condensation of malononitrile 1 , furan‐2‐carbaldehyde 2 , butan‐2‐one 3 , and ammonium acetate in ethanol, followed by cyanoacetylation of the formed nicotinonitrile 4 with 3‐(3,5‐dimethyl‐1H‐pyrazol‐1‐yl)‐3‐oxopropanenitrile 5 afforded the cyanoacetamide 6 . Compound 6 was used as a key intermediate for synthesis of nicotinonitriles via reaction with different reagents. |
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