Fused Heterocycles: Synthesis and Antitubercular Activity of Novel 6‐Substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl)H‐imidazo[1,2‐a]pyridine |
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| Authors: | Yogita K Abhale Keshav K Deshmukh Amit V Sasane Abhijit P Chavan Pravin C Mhaske |
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| Affiliation: | 1. Post‐Graduate and Research, Department of Chemistry, S. N. Arts, D. J. M. Commerce and B. N. S. Science College, Sangamner, District Ahmednagar, India (Affiliated to University of Pune);2. Post Graduate Department of Chemistry, S. P. Mandali's, Sir Parashurambhau College, Pune, India (Affiliated to University of Pune) |
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| Abstract: | A series of 6‐substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl)H‐imidazo1,2‐a]pyridine derivatives 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k , 4l is described. The antitubercular activity of the synthesized compounds was determined against Mycobacterium smegmatis MC2 155 strain. From the activity result, it was found that the phenyl or 4‐fluorophenyl group at 2 position of thiazole nucleus and bromo substituent at 6 position of imidazo1,2‐a]pyridine showed good antitubercular activity. |
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