Heteroatom‐Guided,Palladium‐Catalyzed,Site‐Selective CH Arylation of 4H‐Chromenes: Diastereoselective Assembly of the Core Structure of Myristinin B through Dual CH Functionalization |
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| Authors: | Govind Goroba Pawar Virendra Kumar Tiwari Dr Himanshu Sekhar Jena Dr Manmohan Kapur |
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| Affiliation: | Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Indore Bypass Road, Bhauri, Bhopal 462066, MP (India) |
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| Abstract: | A highly site‐selective, heteroatom‐guided, palladium‐catalyzed direct arylation of 4H‐chromenes is reported. The C?H functionalization is driven not only by the substituents and structure of the substrate but also by the coupling partner being used. The diastereoselective assembly of the core structure of Myristinin B has been achieved by using a dual C?H functionalization strategy for regioselective direct arylation. |
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| Keywords: | arylation C H activation chromenes diastereoselectivity oxygen heterocycles palladium |
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