Pd‐Catalyzed Difluoromethylation of Vinyl Bromides,Triflates, Tosylates,and Nonaflates |
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| Authors: | Dalu Chang Yang Gu Prof. Dr. Qilong Shen |
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| Affiliation: | Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P. R. China) |
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| Abstract: | Pd‐catalyzed difluoromethylation of di‐, tri‐ or tetra‐substituted vinyl bromides, triflates, tosylates and nonaflates under mild conditions is described. The reaction tolerates a wide range of functional groups, such as bromide, chloride, fluoride, ester, amine, nitrile, and protected carbonyl, thus providing a general route for the preparation of difluoromethylated alkenes. |
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| Keywords: | alkenes cross‐coupling fluoroalkylation fluorine palladium |
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