Catalytic Enantioselective α‐Fluorination of 2‐Acyl Imidazoles via Iridium Complexes |
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Authors: | Dr Guo‐Qiang Xu Hui Liang Jie Fang Dr Zhi‐Long Jia Dr Jian‐Qiang Chen Prof?Dr Peng‐Fei Xu |
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Affiliation: | 1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P.R. China;2. (+86)?931‐8915557 |
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Abstract: | The first highly enantioselective α‐fluorination of 2‐acyl imidazoles utilizing iridium catalysis has been accomplished. This transformation features mild conditions and a remarkably broad substrate scope, providing an efficient and highly enantioselective approach to obtain a wide range of fluorine‐containing 2‐acyl imidazoles which are found in a variety of bioactive compounds and prodrugs. A large scale synthesis has also been tested to demonstrate the potential utility of this fluorination method. |
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Keywords: | 2-acyl imidazoles asymmetric catalysis enantioselectivity fluorination iridium |
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