Total Synthesis of Resveratrol‐Based Natural Products Using a Palladium‐Catalyzed Decarboxylative Arylation and an Oxidative Heck Reaction |
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| Authors: | Felix Klotter Prof Dr Armido Studer |
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| Affiliation: | Organisch‐Chemisches Institut, Westf?lische Wilhelms‐Universit?t Münster, Correnstrasse 40, 48149 Münster (Germany) |
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| Abstract: | Controlled access to resveratrol‐based natural products is offered by a novel, modular concept. A common building block readily available on a large scale serves as the starting material for the introduction of structurally important aryl groups by a Pd‐catalyzed decarboxylative arylation and an oxidative Heck reaction with good yields and high stereoselectivity. The modular approach is convincingly documented by the successful synthesis of three racemic resveratrol‐based natural products (quadrangularin A, ampelopsin D, and pallidol). |
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| Keywords: | decarboxylative coupling natural products palladium resveratrol total synthesis |
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