Test‐Strip‐Based Fluorometric Detection of Fluoride in Aqueous Media with a BODIPY‐Linked Hydrogen‐Bonding Receptor |
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| Authors: | Dr Pichandi Ashokkumar Dr Hardy Weißhoff Dr Werner Kraus Dr Knut Rurack |
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| Affiliation: | 1. BAM Bundesanstalt für Materialforschung und ‐prüfung Richard‐Willst?tter‐Strasse 11, 12489 Berlin (Germany);2. Institut für Chemie, Humboldt Universit?t zu Berlin, Brook‐Taylor‐Strasse 2, 12489 Berlin (Germany) |
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| Abstract: | The measurement of biologically relevant anions, such as fluoride, is an important task in analytical chemistry, in particular, for dental health and osteoporosis. Although a large number of fluoride probes are known, the applicability under relevant conditions is limited to a few examples. To improve this situation, BODIPY‐amidothiourea dyes with varying hydrogen‐bond donating strengths were developed, the most H‐acidic of which ( 1 c ) could detect F? from an inorganic source (NaF) in 50 % aqueous solution (DMSO/water 1:1, v/v) with 0.01 ppm sensitivity through selective fluorescence quenching by a photoinduced electron‐transfer (PET) process. Use of the probe and a reference dye with a test‐strip assay and a portable and rapidly recording lateral‐flow fluorescence reader made determination of F? in neat aqueous solutions, such as spiked water samples and toothpaste extracts, possible in a self‐referenced manner, achieving a detection limit of 0.2 ppm. |
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| Keywords: | amidothiourea fluorescent probes fluoride hydrogen bonds photoinduced electron transfer |
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