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The Catalytic Asymmetric α‐Benzylation of Aldehydes |
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| Authors: | Prof?Dr Benjamin List Dr Ilija ?ori? Dr Oleksandr O Grygorenko Philip S J Kaib Prof?Dr Igor Komarov Dr Anna Lee Markus Leutzsch Dr Subhas Chandra?Pan Andrey V Tymtsunik Manuel van?Gemmeren |
| Affiliation: | 1. Max‐Planck‐Institut für Kohlenforschung, Kaiser Wilhelm‐Platz 1, 45470 Mülheim an der Ruhr (Germany);2. Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv (Ukraine) |
| Abstract: | The first aminocatalyzed α‐alkylation of α‐branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α‐branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α‐alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities. |
| Keywords: | α ‐alkylation α ‐branched aldehydes DYKATt enamine catalysis organocatalysis |
