1‐Butyl‐3‐methyl Imidazolium Acetate Catalyzed Synthesis of N‐substituted‐5‐arylidene‐rhodanines |
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| Authors: | Sarangthem Joychandra Singh Sohail Ahmad S M S Chauhan |
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| Affiliation: | Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India |
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| Abstract: | A direct method for the synthesis of N‐substituted‐5‐arylidene‐rhodanines has been reported in high yield via bmim]OAc‐catalyzed one‐pot four‐component domino Knoevenagel condensation of primary amine, carbon disulfide, ethyl chloroacetate, and aromatic aldehyde under neat condition. The catalytic role of bmim]OAc is due to the acidic nature of C‐2 hydrogen of bmim cation and the basic nature of acetate anion in the noncovalent interactions. The synthetic methodology is simple and offers a wide scope for the synthesis of N‐substituted‐5‐arylidene‐rhodanines. |
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