Synthesis of Spirocyclic and Tricyclic Isoxazoline via 1,3‐Dipolar Cycloaddition Reactions |
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| Authors: | Melek Gul Ahmet Tutar |
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| Affiliation: | 1. Faculty of Sciences and Arts, Department of Chemistry, Amasya University, Merkez‐Amasya, Turkey;2. Faculty of Sciences and Arts, Department of Chemistry, Sakarya University, Serdivan‐Sakarya, Turkey |
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| Abstract: | 1,3‐Dipolar cycloadditions of the bicyclic monoterpenes (S)‐(?)‐camphene ( 1 ), (R)‐(+)‐a‐pinene ( 2 ), and (S)‐(?)‐b‐pinene ( 3 ) with aryl and heteroaryl nitrile oxides afforded new spirocyclic and tricyclic isoxazoline derivatives 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 whose biological activities were evaluated in bioassay studies. |
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| Keywords: | bicyclic monoterpene tricyclic isoxazolines spiro‐isoxazolines 1,3‐dipolar cycloaddition reactions |
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