Effectiveness of Photodynamic Therapy in Elimination of HPV‐16 and HPV‐18 Associated with CIN I in Mexican Women |
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| Authors: | Elizabeth Maldonado Alvarado Martha Olivia Osorio Peralta Alejandra Moreno Vázquez Lydia Alejandra Martínez Guzmán Maria Eugenia Melo Petrone Zulma Iveth Enriquez Mar Dora Estela Jovel Galdamez Bárbara Carrión Solana Guadalupe Balderas Martínez Eduarda Parra Rossana Inés Castellanos Oliveros Rosa Linda Bello Leiva Araceli Espinosa Montesinos Citlalli Barrera Mendoza Selma Eugenia Medina García Eva Ramón Gallegos |
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| Affiliation: | 1. Laboratorio de Citopatología Ambiental, Departamento de Morfología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (IPN), Ciudad de México, México;2. Instituto Estatal de Cancerología de Guerrero “Dr. Arturo Beltrán Ortega”, Acapulco Guerrero, México;3. Departamento de Patología, Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Ciudad de México, México;4. Centro de Salud T‐III México‐Espa?a, Ciudad de México, México;5. Comité para la Educación y Desarrollo Integral de la Mujer A.C., San Andrés Tuxtla, Veracruz, México;6. Clínica de Displasias, Hospital Regional “Gral. Ignacio Zaragoza” ISSSTE, Ciudad de México, México |
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| Abstract: | This study aimed to determine the effectiveness of photodynamic therapy (PDT), using δ‐aminolevulinic acid (5‐ALA), in the elimination of premalignant cervical lesions in Mexican patients with human papillomavirus (HPV) infection and/or cervical intraepithelial neoplasia (CIN). Thirty women diagnosed with CIN I and/or positive for HPV participated in the study. Topical 6% 5‐ALA in gel form was applied to the uterine cervix; after 4 h, the lesion area was irradiated with a light dose of 200 J cm?2 at 635 nm. This procedure was performed three times at 48‐h intervals. Clinical follow‐up was performed at 3, 6, and 12 months after the initial PDT administration, by colposcopy, cervical cytology, histopathological analysis, polymerase chain reaction, and hybrid capture. Of HPV‐infected patients without evidence of CIN I, 80% cleared the infection, while HPV associated with CIN I was eliminated in 83% of patients (P < 0.05). At 12 months, CIN I had regressed in 57% of patients, although this response was not statistically significant. PDT using 6% 5‐ALA is concluded to be effective in eliminating HPV infection associated or not with CIN I. |
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