Electrografting of 4‐tert‐Butylcatechol on GC Electrode. Selective Electrochemical Determination of Homocysteine |
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| Authors: | Hamid Salehzadeh Davood Nematollahi Saber Alizadeh |
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| Affiliation: | Faculty of Chemistry, Bu‐Ali Sina University, Hamedan, Iran, Zip Code: 65178‐38683 |
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| Abstract: | A new sensor based on the grafting of 4‐tert‐butylcatechol on the surface of a glassy carbon electrode (GC) was developed for the catalytic oxidation of homocysteine ( Hcy ). The GC‐modified electrode exhibited a reversible redox response at neutral pH. Under the optimum conditions cyclic voltammetric results indicated the excellent electrocatalytic activity of modified electrode toward the oxidation of Hcy at reduced over‐potential about 350 mV. A linear dynamic range of 0.01–3.0 mM and a detection limit of 1.0 µM were obtained for Hcy . The modified electrode was used as an electrochemical sensor for selective determination of Hcy in human blood. |
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| Keywords: | 4‐tert‐Butylcatechol Modified GC electrode Homocysteine Electrocatalysis Surface coverage Electrografting |
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