Rhodium(I)‐Catalyzed Regiospecific Dimerization of Aromatic Acids: Two Direct CH Bond Activations in Water |
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| Authors: | Dr. Hang Gong Dr. Huiying Zeng Dr. Feng Zhou Prof. Dr. Chao‐Jun Li |
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| Affiliation: | 1. Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8 (Canada);2. The Key Laboratory of Environmentally Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105 (China) |
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| Abstract: | 2,2′‐Diaryl acids are key building blocks for some of the most important and high‐performance polymers such as polyesters and polyamides (imides), as well as structural motifs of MOFs (metal–organic frameworks) and biological compounds. In this study, a direct, regiospecific and practical dimerization of simple aromatic acids to generate 2,2′‐diaryl acids has been discovered, which proceeds through two rhodium‐catalyzed C? H activations in water. This reaction can be easily scaled up to gram level by using only 0.4–0.6 mol % of the rhodium catalyst. As a proof‐of‐concept, the natural product ellagic acid was synthesized in two steps by this method. |
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| Keywords: | C H activation cross‐coupling rhodium synthetic methods water chemistry |
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