Pinensins: The First Antifungal Lantibiotics |
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| Authors: | Dr Kathrin I Mohr Dr Carsten Volz Dr Rolf Jansen Dr Victor Wray Dr Judith Hoffmann Dipl‐Ing Steffen Bernecker Priv‐Doz?Dr Joachim Wink Dr Klaus Gerth Prof?Dr Marc Stadler Prof?Dr Rolf Müller |
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| Affiliation: | 1. Mikrobielle Wirkstoffe, Helmholtz Zentrum für Infektionsforschung, Inhoffenstrasse 7, 38124 Braunschweig (Deutschland);2. Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover‐Braunschweig (Deutschland);3. Mikrobielle Naturstoffe, Helmholtz Institut für Pharmazeutische Forschung Saarland, Helmholtz Zentrum für Infektionsforschung und Pharmazeutische Biotechnologie, Universit?t des Saarlandes, Campus C2.3, 66123 Saarbrücken (Deutschland);4. Helmholtz Zentrum für Infektionsforschung, Inhoffenstrasse 7, 38124 Braunschweig (Deutschland);5. Mikrobielle Stammsammlung, Helmholtz Zentrum für Infektionsforschung, Inhoffenstrasse 7, 38124 Braunschweig (Deutschland) |
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| Abstract: | Lantibiotics (lanthionine‐containing antibiotics) from Gram‐positive bacteria typically exhibit activity against Gram‐positive bacteria. The activity and structure of pinensin A ( 1 ) and B ( 2 ), lantibiotics isolated from a native Gram‐negative producer Chitinophaga pinensis are described. Surprisingly, the pinensins were found to be highly active against many filamentous fungi and yeasts but show only weak antibacterial activity. To the best of our knowledge, lantibiotic fungicides have not been described before. An in‐depth bioinformatic analysis of the biosynthetic gene cluster established the ribosomal origin of these compounds and identified candidate genes encoding all of the enzymes required for post‐translational modification. Additional encoded functions enabled us to build up a hypothesis for the biosynthesis, export, sensing, and import of this intriguing lantibiotic. |
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| Keywords: | biosynthesis Chitinophaga pinensis fungicides Gram‐negative bacteria lantibiotics |
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