Stochasticity in the yeast mating pathway |
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| Authors: | Wang Hong-Li Fu Zheng-Ping Xu Xin-Hang and Ouyang Qi |
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| Affiliation: | State Key Laboratory for Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China; The Beijing-Hong Kong-Singapore Joint Center for Nonlinear and Complex Systems (PKU); Center for Theoretical Biology, Peking University,Beijing 100871, China |
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| Abstract: | We report stochastic simulations of the yeast mating signal
transduction pathway. The effects of intrinsic and external noise,
the influence of cell-to-cell difference in the pathway capacity,
and noise propagation in the pathway have been examined. The
stochastic temporal behaviour of the pathway is found to be robust
to the influence of inherent fluctuations, and intrinsic noise
propagates in the pathway in a uniform pattern when the yeasts are
treated with pheromones of different stimulus strengths and of varied
fluctuations. In agreement with recent experimental findings,
extrinsic noise is found to play a more prominent role than
intrinsic noise in the variability of proteins. The occurrence
frequency for the reactions in the pathway are also examined and a
more compact network is obtained by dropping most of the reactions
of least occurrence. |
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| Keywords: | noise stochastic simulation pheromone response mating pathway of yeast |
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