Vinmajorines C – E,Monoterpenoid Indole Alkaloids from Vinca major |
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| Authors: | Juan He Xing‐De Wu Yan Li Rong‐Tao Li Qin‐Shi Zhao |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming 650204, P.?R. China, (phone: +86‐871‐65223058;2. fax: +86‐871‐65215783);3. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P.?R. China, (phone: +86‐871‐65920569;4. fax: +86‐871‐65920570) |
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| Abstract: | Three new monoterpenoid indole alkaloids, vinmajorines C–E ( 1 – 3 ), along with 18 known analogues ( 4 – 21 ), were isolated from the whole plants of Vinca major. The new structures were elucidated as (5α,15β,16R,17α,19β,20α,21β)‐10,17‐dimethoxy‐21‐methyl‐18‐oxa‐5,16‐cycloyohimban‐19‐ol ( 1 ), (5α,15β,16R,17α,20α,21β)‐10‐methoxy‐21‐methyl‐18‐oxa‐5,16‐cycloyohimban‐17‐ol ( 2 ), and (5α,15β,16R,17α,20α,21β)‐10‐methoxy‐21‐methyl‐18‐oxa‐5,16‐cycloyohimban‐17‐yl acetate ( 3 ), respectively, by extensive NMR and MS analysis and comparison with known compounds. Compounds 1 – 3 were evaluated for their cytotoxic activities against five human cancer cell lines, compounds 1 and 3 showing moderate cytotoxic activities. |
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| Keywords: | Vinca major Monoterpenoid indole alkaloid Vinmajorines C – E Cytotoxic activity |
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