Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug‐Resistant Pseudomonas aeruginosa |
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| Authors: | Michaela Stach Thissa N. Siriwardena Dr. Thilo Köhler Prof. Dr. Christian van Delden Priv.‐Doz. Dr. Tamis Darbre Prof. Dr. Jean‐Louis Reymond |
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| Affiliation: | 1. Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern (Switzerland);2. Department of Microbiology and Molecular Medicine, University of Geneva and Service of Infectious Diseases, University Hospital of Geneva, Geneva (Switzerland) |
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| Abstract: | Multidrug‐resistant opportunistic bacteria, such as Pseudomonas aeruginosa, represent a major public health threat. Antimicrobial peptides (AMPs) and related peptidomimetic systems offer an attractive opportunity to control these pathogens. AMP dendrimers (AMPDs) with high activity against multidrug‐resistant clinical isolates of P. aeruginosa and Acinetobacter baumannii were now identified by a systematic survey of the peptide sequences within the branches of a distinct type of third‐generation peptide dendrimers. Combined topology and peptide sequence design as illustrated here represents a new and general strategy to discover new antimicrobial agents to fight multidrug‐resistant bacterial pathogens. |
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| Keywords: | antibiotics antimicrobial peptides dendrimers Pseudomonas aeruginosa peptides |
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