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β‐Functionalization of Carboxylic Anhydrides with β‐Alkyl Substituents through Carbene Organocatalysis |
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| Authors: | Zhichao Jin Shaojin Chen Yuhuang Wang Pengcheng Zheng Prof Dr Song Yang Prof Dr Yonggui Robin Chi |
| Affiliation: | 1. Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore);2. Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025 (China) |
| Abstract: | The first NHC‐catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the β carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging β‐alkyl substituents work effectively. |
| Keywords: | anhydrides asymmetric synthesis N‐heterocyclic carbenes organocatalysis β ‐functionalization |
