Diversity study of 12 X‐chromosomal STR loci in Hui ethnic from China |
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| Authors: | Yu‐Dang Zhang Wen‐Juan Liu Tian‐Ju Wang Jiang‐Wei Yan Jing‐Feng Huang Wei‐An Du Jian‐Xin Guo Hong‐Dan Wang Yu‐Hong Zhang Ru‐Hua Zhou Xing Wei |
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| Affiliation: | 1. Xi'an Jiaotong University, Health Science Center, Xi'an, P. R. China***;2. Blood Center of Shaanxi Province, Xi'an, P. R. China;3. Beijing Institute of Genomics, Chinese Academy of Science, Beijing, P. R. China;4. First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, P. R. China;5. Medical Genetic Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, P. R. China;6. Criminal Police Detachment of Nantong City Public Security Bureau, Nantong, P. R. China;7. Criminal Police Detachment of Suzhou City Public Security Bureau, Suzhou, P. R. China |
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| Abstract: | X‐chromosomal STRs (X‐STRs) have been used as complements of autosomal STR application in recent years. In this work, we present population genetic data of 12 X‐STRs including DXS101, DXS10159, DXS10162, DXS10164, DXS6789, DXS7133, DXS7423, DXS7424, DXS8378, DXS981, GATA165B12, and GATA31E08 loci in a sample of 231 unrelated healthy individuals from the Hui ethnic group in Ningxia Hui Autonomous Region, China. Allelic frequencies of the 12 X‐STR loci and haplotypic frequencies of the reported linkage groups (DXS7424‐DXS101 and DXS10159‐DXS10164‐DXS10162) were investigated in the group, respectively. No STR loci showed significant deviations from the Hardy–Weinberg equilibriums and no linkage disequilibriums of pairwise loci were found after Bonferroni correction, respectively. A combined power of discrimination in female individuals was 0.999999999985 and that in male individuals was 0.99999967, respectively. The combined mean exclusion chance in deficiency cases, normal trios and duo cases were 0.999934, 0.995754, and 0.999796, respectively. Significant differences were observed from 0 to 8 loci, when making comparisons between the data of Hui ethnic group and previously reported data from other 16 populations. The results indicated the new panel of 12 X‐STR loci might be useful for forensic science application. |
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| Keywords: | Genetic polymorphisms Hui ethnic group Population genetics X‐STRs |
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