Scalable Synthesis of Piperazines Enabled by Visible‐Light Irradiation and Aluminum Organometallics |
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| Authors: | Dr. Samuel Suárez‐Pantiga Kilian Colas Dr. Magnus J. Johansson Dr. Abraham Mendoza |
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| Affiliation: | 1. Department of Organic Chemistry and Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 10691 Stockholm (Sweden) http://www.organ.su.se/am/;2. Innovative Medicines, Cardiovascular and Metabolic Diseases, Medicinal Chemistry, AstraZeneca R&D, Pepparedsleden 1, 43183 M?lndal (Sweden) |
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| Abstract: | The development of more active C? H oxidation catalysts has inspired a rapid, scalable, and stereoselective assembly of multifunctional piperazines through a [3+3] coupling of azomethine ylides. A combination of visible‐light irradiation and aluminum organometallics is essential to promote this transformation, which introduces visible‐light photochemistry of main‐group organometallics and sets the basis for new and promising catalysts. |
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| Keywords: | aluminum cycloaddition heterocycles oxidation photochemistry |
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