Clickable Nucleic Acids: Sequence‐Controlled Periodic Copolymer/Oligomer Synthesis by Orthogonal Thiol‐X Reactions |
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| Authors: | Weixian Xi Dr Sankha Pattanayak Chen Wang Dr Benjamin Fairbanks Dr Tao Gong Justine Wagner Prof?Dr Christopher J Kloxin Prof?Dr Christopher N Bowman |
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| Affiliation: | 1. Department of Chemical & Biological Engineering, University of Colorado Boulder, 596 UCB, Boulder, Colorado 80309‐0596 (USA);2. Department of Materials Science & Engineering and Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, Delaware 19716 (USA) |
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| Abstract: | Synthetic polymer approaches generally lack the ability to control the primary sequence, with sequence control referred to as the holy grail. Two click chemistry reactions were now combined to form nucleobase‐containing sequence‐controlled polymers in simple polymerization reactions. Two distinct approaches are used to form these click nucleic acid (CNA) polymers. These approaches employ thiol–ene and thiol‐Michael reactions to form homopolymers of a single nucleobase (e.g., poly(A)n) or homopolymers of specific repeating nucleobase sequences (e.g., poly(ATC)n). Furthermore, the incorporation of monofunctional thiol‐terminated polymers into the polymerization system enables the preparation of multiblock copolymers in a single reaction vessel; the length of the diblock copolymer can be tuned by the stoichiometric ratio and/or the monomer functionality. These polymers are also used for organogel formation where complementary CNA‐based polymers form reversible crosslinks. |
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| Keywords: | block copolymers click chemistry polymerization thiols |
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