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Metal‐Free Oxidative CC Bond Formation through CH Bond Functionalization |
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| Authors: | Dr Rishikesh Narayan Dr Kiran Matcha Dr Andrey P Antonchick |
| Affiliation: | 1. Abteilung Chemische Biologie, Max‐Planck‐Institut für Molekulare Physiologie, Otto‐Hahn Strasse 11, 44227 Dortmund (Germany);2. Present Address: API Small Molecule Process Research and Development, Janssen Pharmaceutica NV, Turnhotsweg 30, 2340 Beerse (Belgium);3. Fakult?t Chemie und Chemische Biologie, Technische Universit?t Dortmund, Otto‐Hahn Strasse 6, 44221 Dortmund (Germany) |
| Abstract: | The formation of C?C bonds embodies the core of organic chemistry because of its fundamental application in generation of molecular diversity and complexity. C?C bond‐forming reactions are well‐known challenges. To achieve this goal through direct functionalization of C?H bonds in both of the coupling partners represents the state‐of‐the‐art in organic synthesis. Oxidative C?C bond formation obviates the need for prefunctionalization of both substrates. This Minireview is dedicated to the field of C?C bond‐forming reactions through direct C?H bond functionalization under completely metal‐free oxidative conditions. Selected important developments in this area have been summarized with representative examples and discussions on their reaction mechanisms. |
| Keywords: | C C coupling C H activation hypervalent iodine metal‐free oxidative coupling |
