Enantioseparation of citalopram analogues with sulfated β‐cyclodextrin by capillary electrophoresis |
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| Authors: | Yadi Wang Shusheng Zhang Zachary S Breitbach Hans Petersen Peter Ellegaard Daniel W Armstrong |
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| Affiliation: | 1. Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, USA;2. College of Chemistry & Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China;3. H. Lundbeck A/S, Chemical Process Research, Valby, Denmark |
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| Abstract: | Capillary electrophoresis methods were developed for the enantiomeric separation of 27 citalopram analogues. Sulfated β‐cyclodextrin was the most broadly selective and useful chiral selector. The separations of most of the citalopram analogue compounds reported in this work have not been reported previously. Excellent enantiomeric separations were obtained for 26 out of 27 compounds, and most of the separations were achieved within 10 min. The effects of chemical parameters such as chiral selector types, buffer types, chiral selector and buffer concentrations, buffer pH and organic modifiers on the separation were investigated. The influence of analyte structure on separation also was examined and discussed. |
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| Keywords: | Chiral capillary electrophoresis Citalopram Enantioseparation Sulfated β ‐cyclodextrin |
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