Site‐Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome |
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| Authors: | Dr Seah Ling Kuan Dr Tao Wang Prof?Dr Tanja Weil |
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| Affiliation: | 1. Institute of Organic Chemistry III, Ulm University, Ulm, Germany;2. Max Planck Institute for Polymer Research, Mainz, Germany;3. School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, P.R. China |
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| Abstract: | The synthetic transformation of polypeptides with molecular accuracy holds great promise for providing functional and structural diversity beyond the proteome. Consequently, the last decade has seen an exponential growth of site‐directed chemistry to install additional features into peptides and proteins even inside living cells. The disulfide rebridging strategy has emerged as a powerful tool for site‐selective modifications since most proteins contain disulfide bonds. In this Review, we present the chemical design, advantages and limitations of the disulfide rebridging reagents, while summarizing their relevance for synthetic customization of functional protein bioconjugates, as well as the resultant impact and advancement for biomedical applications. |
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| Keywords: | bioactive hybrids disulfide rebridging drug delivery multimodal proteins site-selective protein modifications |
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