Nickel‐ and Photoredox‐Catalyzed Cross‐Coupling Reactions of Aryl Halides with 4‐Alkyl‐1,4‐dihydropyridines as Formal Nucleophilic Alkylation Reagents |
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| Authors: | Dr Kazunari Nakajima Sunao Nojima Prof Dr Yoshiaki Nishibayashi |
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| Affiliation: | Department of Systems Innovation, School of Engineering, The University of Tokyo, Tokyo, Japan |
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| Abstract: | A combination of nickel and photoredox catalysts promoted novel cross‐coupling reactions of aryl halides with 4‐alkyl‐1,4‐dihydropyridines. 4‐Alkyl‐1,4‐dihydropyridines act as formal nucleophilic alkylation reagents through a photoredox‐catalyzed carbon–carbon (C?C) bond‐cleavage process. The present strategy provides an alternative to classical carbon‐centered nucleophiles, such as organometallic reagents. |
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| Keywords: | C− C cleavage cross-coupling dihydropyridines nickel catalysts photoredox catalysts |
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