Copper(II)‐Catalyzed Nitroaldol (Henry) Reactions: Recent Developments |
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| Authors: | Govindarasu Murugavel Pradeep Sadhu Tharmalingam Punniyamurthy |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, India |
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| Abstract: | Self‐assembled copper(II) complexes are described as effective catalysts for nitroaldol (Henry) reactions on water. The protocol involves a heterogeneous process and the catalysts can be recovered and recycled without loss of activity. Further, C2‐symmetric N,N′‐substituted chiral copper(II) salan complexes are found to be more effective catalysts than chiral copper(II) salen complexes for reactions in homogeneous catalysis, with high enantioselectivities. The reactions involve bifunctional catalysis, bearing the properties of a Brønsted base, as well as a Lewis acid, to effect the reaction in the absence of external additives. |
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| Keywords: | acceleration of reactions enantioselectivity heterogeneous catalysis homogeneous catalysis nitroaldol reactions |
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