Synthesis of Optically Active 2‐Amino‐1,3,4‐oxadiazoles and their Hybrid Peptides |
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| Authors: | Chilakapati Madhu Girish Prabhu Rumpa Pal T N Guru Row Vommina V Sureshbabu |
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| Affiliation: | 1. Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore, India;2. Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore, India |
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| Abstract: | Synthesis of 2‐amino‐1,3,4‐oxadiazole derivatives of Nα‐Cbz(benzyloxycarbonyl)/Boc‐protected amino/peptide acids under sonication is described. The conditions involved in the present protocol are simple, mild, and racemization free. The utility of 2‐amino group in the substituted oxadiazoles for the incorporation of peptide and ureido bonds to obtain hybrid peptidomimetics is also delineated. The 2‐amino‐1,3,4‐oxadiazole 3b was obtained as a single crystal, and its molecular structure has been confirmed through X‐ray crystallographic study. |
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