Photoresponsive Formation of an Intermolecular Minimal G‐Quadruplex Motif |
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| Authors: | Julie Thevarpadam Irene Bessi Oliver Binas Dr Diana P N Gonçalves Dr Chavdar Slavov Dr Hendrik R A Jonker Dr Christian Richter Prof Dr Josef Wachtveitl Prof Dr Harald Schwalbe Prof Dr Alexander Heckel |
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| Affiliation: | 1. Goethe University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Frankfurt, Germany;2. Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Frankfurt, Germany;3. Institute for Physical and Theoretical Chemistry, Frankfurt, Germany;4. http://schwalbe.org.chemie.uni‐frankfurt.de;5. http://photochem.uni‐frankfurt.de |
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| Abstract: | The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two‐tetrad G‐quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G‐quadruplexes with K+ ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para–para‐substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G‐quadruplex and an unstructured state after E–Z isomerization. |
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| Keywords: | azobenzene DNA structures G-quadruplexes IR spectroscopy NMR spectroscopy |
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