Knoevenagel Adducts as Trimethylenemethane Dipole Surrogates |
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| Authors: | Prof Alexander J Grenning |
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| Affiliation: | Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville FL 32611‐7200 (USA) http://grenning.chem.ufl.edu |
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| Abstract: | Knoevenagel adducts derived from readily available acetoxyacetone and malonic acid derivatives served as trimethylenemethane surrogates for formal 1,3‐difunctionalization through a sequence of selective γ‐deprotonation/α‐alkylation and palladium(0)‐catalyzed allylic alkylation. Herein, we report the discovery and development of a three‐component 1,3‐difunctionalization of Knoevenagel adducts as well as a unique palladium(0)‐catalyzed branch‐selective allylic alkylation. |
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| Keywords: | 1 3‐difunctionalization allylation Knoevenagel condensation palladium catalysis trimethylenemethane |
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