Two New Phenolic Compounds from Artemisia iwayomogi |
| |
| Authors: | Xi‐Tao Yan Yan Ding Wei Li Ya‐Nan Sun Seo‐Young Yang Young‐Sang Koh Young‐Ho Kim |
| |
| Affiliation: | 1. College of Pharmacy, Chungnam National University, Daejeon 305‐764, Korea, (phone:+82‐42‐821‐5933;2. fax: +82‐42‐823‐6566);3. School of Food Science and Technology, Dalian Polytechnic University, Dalian 116‐034, P.?R. China;4. School of Medicine, Jeju National University, Jeju 690‐756, Korea |
| |
| Abstract: | Two new phenolic compounds, (Z)‐5′‐hydroxyjasmone 5′‐O‐{6″‐O‐(E)‐caffeoyl]‐β‐D ‐glucopyranoside} ( 1 ) and quercetin‐7‐O‐β‐D ‐glucuronide methyl ester ( 2 ), along with ten known phenolic compounds, 3 – 12 , were isolated from the aerial parts of Artemisia iwayomogi. Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR, and HR‐ESI‐TOF‐MS techniques. The inhibitory effects of compounds 1 – 12 on the LPS‐stimulated production of IL‐12 p40, IL‐6, and TNF‐α in bone marrow‐derived dendritic cells were evaluated. |
| |
| Keywords: | Artemisia iwayomogi Phenolic compounds Anti‐inflammatory activity IL‐12 p40 |
|
|
