Suberosanones A – C,New Metabolites Possessing Cyclopentenone System from the South China Sea Gorgonian Coral Subergorgia suberosa |
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| Authors: | Jun Zhang Yan Liang Liang‐Chun Li Shi‐Hai Xu |
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| Affiliation: | 1. College of Pharmacy, Jinan University, Guangzhou 510632, P.?R. China (phone: +86‐20‐85221236);2. Department of Chemistry, Jinan University, Guangzhou 510632, P.?R. China;3. Division of Life Science, School of Science, The Hong Kong University of Science and Technology, Hong Kong SAR, P.?R. China;4. School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, P.?R. China |
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| Abstract: | Two unusual novel bicyclic lactones, suberosanones A and B ( 1 and 2 , resp.), characterized by the co‐occurrence of cyclopentenone and butanolide rings within the same molecule, along with one tricyclic cyclopentenone derivative, suberosanone C ( 3 ), were isolated from the South China Sea gorgonian coral Subergorgia suberosa. Their structures were unambiguously established by detailed spectroscopic analyses (NMR, IR, and HR‐MS). The absolute configurations of 1 and 2 were determined by quantum‐chemical calculations using the time‐dependent density‐functional theory (TDDFT) method. All compounds showed neither antifouling activity against Balanus amphitrite larvae settlement nor antibacterial activity against a panel of bacterial strains at concentrations up to 25 μg/ml. |
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| Keywords: | Subergorgia suberosa Lactones Metabolites Suberosanones A – C Corals |
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