Formation of Phosphorylated 3H‐Pyrroles from NefIsocyanidePerkow Adducts and Tosylmethyl Isocyanide |
| |
| Authors: | Issa Yavari Ehsan Ghanbari Reza Hosseinpour |
| |
| Affiliation: | 1. Department of Chemistry, Tarbiat Modares University, P.O. Box 14115‐175, Tehran, Iran, (phone: +98‐21‐82883465;2. fax: +98‐21‐82883455) |
| |
| Abstract: | Imidoyl chlorides, generated from isocyanides and acyl chlorides, react with trialkyl phosphites, in a Perkow‐type reaction, to afford 3‐(alkylimino)‐2‐(dialkyloxyphosphoryl)oxy]acrylates, which undergo a smooth reaction with tosylmethyl isocyanide (TsMIC) to furnish 4‐(alkylamino)‐3‐(dialkyloxyphosphoryl)oxy]‐5‐(4‐methylphenyl)sulfonyl]‐3H‐pyrrole‐3‐carboxylates in moderate‐to‐good yields. |
| |
| Keywords: | Perkow reaction Ketenimines 3H‐Pyrroles Cyclization reactions |
|
|
