Secondary Metabolites from the Endophytic Fungus Xylaria cubensis |
| |
| Authors: | Hsun‐Shuo Chang Sung‐Yuan Hsieh Ta‐Wei Liu Gwo‐Fang Yuan Ih‐Sheng Chen |
| |
| Affiliation: | 1. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan;2. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, (phone: +886‐3‐5223191 (ext 580));3. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan (phone: +886‐7‐3121101 (ext 2191)) |
| |
| Abstract: | Seven new metabolites, including three sesquiterpenoids, 10‐hydroxythujopsene ( 1 ), akotriol ( 2 ), and xylaritriol ( 3 ), one diterpenoid, cubentriol ( 4 ), one aliphatic derivative, akoenic acid ( 5 ), one alkaloid, akodionine ( 6 ), and one isocoumarin, akolitserin ( 7 ), together with seven known compounds, 8 – 14 , were isolated from the AcOEt‐soluble fraction of the fermentation broth of the endophytic fungus Xylaria cubensis, derived from the leaves of Litsea akoensis Hayata (Lauraceae). Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments, and by HR‐ESI‐MS mass spectrometry. Among the isolates, (?)‐(R)‐7‐hydroxymellein showed IL‐6 inhibitory activity with an IC50 value of 9.41 μM . |
| |
| Keywords: | Xylaria cubensis Metabolites NO Inhibitory activity IL‐6 Inhibitory activity |
|
|
