Regioselective,Solvent‐ and Metal‐Free Chalcogenation of Imidazo[1,2‐a]pyridines by Employing I2/DMSO as the Catalytic Oxidation System |
| |
| Authors: | Dr. Jamal Rafique Dr. Sumbal Saba Dr. Alisson R. Rosário Prof. Dr. Antonio L. Braga |
| |
| Affiliation: | 1. http://labselen.ufsc.com/ 0000-0002-2336-040X Departamento de Química, Universidade Federal de Santa Catarina, Florianopolis, Brazil;2. Departamento de Química, Universidade Federal de Santa Catarina, Florianopolis, Brazil |
| |
| Abstract: | ![]()
Highly efficient molecular‐iodine‐catalyzed chalcogenations (S and Se) of imidazo[1,2‐a]pyridines were achieved by using diorganoyl dichalcogenides under solvent‐free conditions. This approach afforded the desired products that had been chalcogenated regioselectively at the C3 position in up to 96 % yield by using DMSO as an oxidant, in the absence of a metal catalyst, and under an inert atmosphere. This mild, green approach allowed the preparation of different types of chalcogenated imidazo[1,2‐a]pyridines with structural diversity. Furthermore, the current protocol was also extended to other N‐heterocyclic cores. |
| |
| Keywords: | green chemistry iodine nitrogen heterocycles selenium sulfur |
|
|
