Low‐Pressure Cobalt‐Catalyzed Enantioselective Hydrovinylation of Vinylarenes |
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| Authors: | Dr Sohajl Movahhed Julia Westphal Dr Mehmet Dindaro?lu Dr Anna Falk Prof?Dr Hans‐Günther Schmalz |
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| Affiliation: | Department of Chemistry, University of Cologne, Cologne, Germany |
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| Abstract: | An efficient and practical protocol for the enantioselective cobalt‐catalyzed hydrovinylation of vinylarenes with ethylene at low (1.2 bar) pressure has been developed. As precatalysts, stable L2CoCl2] complexes are employed that are activated in situ with Et2AlCl. A modular chiral TADDOL‐derived phosphine–phosphite ligand was identified that allows the conversion of a broad spectrum of substrates, including heterocyclic vinylarenes and vinylferrocene, to smoothly afford the branched products with up to 99 % ee and virtually complete regioselectivity. Even polar functional groups, such as OH, NH2, CN, and CO2R, are tolerated. |
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| Keywords: | alkenes asymmetric catalysis C− C bond formation chirality cobalt |
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