| 利用Monte-Carlo模拟评价基因水平的关联分析方法 |
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| 引用本文： | 桂娟娟 罗旭红 张添方 华启航 董长征.利用Monte-Carlo模拟评价基因水平的关联分析方法[J].宁波大学学报(理工版),2015,0(4):104-108. |
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| 作者姓名： | 桂娟娟 罗旭红 张添方 华启航 董长征 |
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| 作者单位： | 宁波大学 医学院, 浙江 宁波 3152111 |
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| 摘 要： | 采用Monte-Carlo模拟了多种参数条件下的遗传关联数据, 计算多种基因水平的关联分析方法的统计效能. 结果显示: 主成分Logistic回归分析(累积贡献率为95%)和我们之前发展的基于LD结构和Fisher组合法的新方法(LD-Fisher)在多种参数条件下都具有很高的统计效能, Fisher组合法只有在单个易感SNP的P值较小时或者存在多个P值不太小的易感SNP时表现较好. 主成分Logistic回归分析和LD-Fisher可以作为基因水平关联分析的较为理想的分析方法.
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| 关 键 词： | 遗传关联数据 基因水平的关联分析 Monte-Carlo模拟 统计效能 |
Evaluation of Gene Based Association Tests by Monte-Carlo Simulation |
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| GUI Juan-juan,LUO Xu-hong,ZHANG Tian-fang,HUA Qi-hang,DONG Chang-zheng.Evaluation of Gene Based Association Tests by Monte-Carlo Simulation[J].Journal of Ningbo University(Natural Science and Engineering Edition),2015,0(4):104-108. |
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| Authors: | GUI Juan-juan LUO Xu-hong ZHANG Tian-fang HUA Qi-hang DONG Chang-zheng |
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| Affiliation: | School of Medicine, Ningbo University, Ningbo 315211, China |
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| Abstract: | Monte-Carlo is adopted to evaluate the power of multiple gene based association tests. With PCA logistic regression (95% cumulative variance) and our previously developed method, the LD-Fisher is found to have the highest power, and performs well under all simulated circumstances. Fisher combination test presents high power only if the P value of the susceptibility SNP takes very small value or there are multiple susceptibility SNPs. In conclusion, PCA logistic regression and LD-Fisher can be used as gene based association tests for complex diseases. |
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| Keywords: | genetic association data gene based association test Monte-Carlo simulation power |
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