Catalytic Enantioselective Decarboxylative Allylations of a Mixture of Allyl Carbonates and Allyl Esters: Total Synthesis of (−)‐ and (+)‐Folicanthine |
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| Authors: | Prof. Dr. Alakesh Bisai |
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| Affiliation: | Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal ‐ 462066, Madhya Pradesh (India) |
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| Abstract: | ![]()
A highly enantioselective decarboxylative allylation of a mixture of enol carbonates and allyl esters has been achieved. The strategic viability of this methodology has been demonstrated through the total synthesis of cyclotryptamine alkaloids (?)‐ and (+)‐folicanthine ( 1 a ) and the formal total synthesis of (?)‐chimonanthine ( 1 b ), (+)‐calycanthine ( 1 c ), and (?)‐ditryptophenaline ( 1 d ). |
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| Keywords: | alkaloids allylation enantioselectivity palladium quaternary stereocentres |
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