Dual‐Pore Mesoporous Carbon@Silica Composite Core–Shell Nanospheres for Multidrug Delivery |
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| Authors: | Yin Fang Prof Gengfeng Zheng Jianping Yang Haosha Tang Yafeng Zhang Biao Kong Yingying Lv Prof Congjian Xu Prof Abdullah M Asiri Prof Jian Zi Prof Fan Zhang Prof Dongyuan Zhao |
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| Affiliation: | 1. Department of Chemistry and Shanghai Key Lab of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers and Advanced Materials Laboratory, Fudan University, Shanghai 200433 (P.R. China);2. Obstetrics and Gynecology Hospital of Fudan University (China);3. Department of Physics, Fudan University (China);4. Chemistry Department and The Center of Excellence for Advanced Materials Research, King Abdulaziz University (Saudi Arabia) |
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| Abstract: | Monodispersed mesoporous phenolic polymer nanospheres with uniform diameters were prepared and used as the core for the further growth of core–shell mesoporous nanorattles. The hierarchical mesoporous nanospheres have a uniform diameter of 200 nm and dual‐ordered mesopores of 3.1 and 5.8 nm. The hierarchical mesostructure and amphiphilicity of the hydrophobic carbon cores and hydrophilic silica shells lead to distinct benefits in multidrug combination therapy with cisplatin and paclitaxel for the treatment of human ovarian cancer, even drug‐resistant strains. |
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| Keywords: | core– shell structures drug delivery mesoporous materials nanoparticles photonic crystals |
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