Multisite Organic–Inorganic Hybrid Catalysts for the Direct Sustainable Synthesis of GABAergic Drugs |
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Authors: | Dr Antonio Leyva‐Pérez Dr Pilar García‐García Prof?Dr Avelino Corma |
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Affiliation: | Instituto de Tecnología Química, UPV‐CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv‐csic.es/en/ |
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Abstract: | Multisite organic–inorganic hybrid catalysts have been prepared and applied in a new general, practical, and sustainable synthetic procedure toward industrially relevant GABA derivatives. The domino sequence is composed of seven chemical transformations which are performed in two one‐pot reactions. The method produces both enantiomeric forms of the product in high enantiopurity as well as the racemate in good yields after a single column purification step. This protocol highlights major process intensification, catalyst recyclability, and low waste generation. |
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Keywords: | γ ‐aminobutyric acid domino reactions GABAergic drug synthesis heterogeneous catalysis organic– inorganic hybrid catalysts |
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